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Immunohistochemical and biomolecular identification of 5-HT_{7} receptor in rat vestibular nuclei
Featured Article (1,302 KB)
pp. 401 - 406
Roza Khalmuratova, Young-Sool Hah, Seong-Ki Ahn, Sea-Yuong Jeon, Jin-Pyeong Kim, Carey D. Balaban

The association between migraine and balance disorder morbidities has been a topic of interest for many years, and serotonin (5-HT) receptor is known to be closely related with migraine and also to be associated with vestibular symptoms. However, the mechanism underlying the pathogenesis of migrainous vertigo and its association with 5-HT has not been elucidated. Of the many 5-HT receptors, 5-HT_{7} receptor has recently attracted attention in the context of migraine treatment. The purpose of this study was to investigate the localization and expression of 5-HT_{7} receptor in the rat vestibular nuclei by immunohistochemical staining and reverse transcriptase-polymerase chain reaction (RT-PCR). The present study might provide additional insight into the role of 5-HT_{7} receptor in the pathogenesis of migraine-related vestibular symptoms.